Analysis of the Effect of Dental Implant Therapy on Serum Metal Ion Levels: An Observational Study

The research was carried out for the evaluation of serum metal ion concentrations in dental implant subjects.

The study comprised 50 individuals, with 26 being male and 24 being female. Before inserting the implant, serum samples had been taken from every individual to determine the initial amounts of titanium and aluminum ions. Each patient had 10 milliliters of blood extracted into sterile vacutainers, without the addition of any anticoagulant. The blood had been permitted to coagulate precisely for 20 minutes at room temperature, and thereafter subjected to centrifugation to get serum. Prolonged incubation could potentially lead to the introduction of external contaminants. Inductively coupled plasma optical emission spectrometry (ICP-OES) was employed to evaluate the samples for titanium and aluminum. Subsequently, implants were inserted via a flapless approach. Serum samples were obtained on follow-up and results were assessed.

Mean titanium amounts prior to placement of dental implants were 3.24 mg/dl. The mean titanium levels at six weeks, three months, and six months following implant placement were 3.26 mg/dl, 3.29 mg/dl, and 3.31 mg/dl, respectively. Mean aluminum levels before placement of dental implants were 4.21 mg/dl. The mean titanium levels at six weeks, three months, and six months following implant placement were 4.25 mg/dl, 4.27 mg/dl, and 4.3 mg/dl, respectively.

No effect in serum titanium and aluminum levels occurs after dental implant placement.