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Updated: Mar 19, 2026
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Efficacy of Integrating Immunotherapy with Surgical Resection in Oral Squamous Cell Carcinoma: A Clinical Study
Kala Bagavathy1, Angshuman Saha2, Maryada Sravani3
1Department of Oral and Maxillofacial Surgery, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India.
Purpose:
This research evaluates the efficacy of integrating immunotherapy with surgical resection in the treatment of "oral squamous cell carcinoma (OSCC)." By analyzing clinical outcomes, we aim to provide evidence for a combined therapeutic approach.
Methods:
A cohort of 120 OSCC patients was divided into two groups: surgical resection alone (n = 60) and surgical resection with adjunctive immunotherapy (n = 60). Treatment outcomes were assessed using survival rates, recurrence rates, and quality-of-life indicators.
Results:
Patients in the combined therapy group showed significantly improved three-year overall survival (78% vs. 62%) and reduced recurrence rates (15% vs. 28%). Quality-of-life scores were also higher in the immunotherapy group.
Conclusion:
Integrating immunotherapy with surgical resection improves clinical outcomes in OSCC, suggesting a promising direction for multimodal treatment strategies.
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