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Updated: Mar 19, 2026

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Promotion of breast cancer by the DNPH1 enzyme

Sangphil Oh1,2, Yuan Sui3, Sook Shin1,2

  • 1Department of Cell Biology, University of Oklahoma Health Campus, Oklahoma City, OK 73104, USA.

Iscience
|March 18, 2026
PubMed

Insights

The DNPH1 enzyme is overexpressed in multiple cancers, driving tumor growth and stem cell function. Inhibiting DNPH1 shows promise as a novel cancer therapy strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The role of the DNPH1 enzyme in cancer pathophysiology is largely unknown.
  • Understanding novel molecular targets is crucial for advancing cancer therapy.

Purpose of the Study:

  • To investigate the function and significance of the DNPH1 enzyme in breast cancer.
  • To explore DNPH1's role in other tumor types and its therapeutic potential.

Main Methods:

  • Assessed DNPH1 expression in human tumor samples (breast, prostate, lung).
  • Utilized gene downregulation and knockout models in cancer cell lines and mice.
  • Analyzed tumor growth, stem cell properties, angiogenesis, and molecular signaling pathways (AMPK, YAP1).

Main Results:

  • DNPH1 is overexpressed in breast, prostate, and lung tumors, correlating with aggressiveness.
  • DNPH1 downregulation reduced cancer cell oncogenicity and compromised stem cells.
  • Dnph1 knockout in mice impaired HER2-mediated mammary tumor formation, angiogenesis, and altered AMP/AMPK/YAP1 signaling.

Conclusions:

  • DNPH1 plays a significant role in cancer cell oncogenicity and tumor development.
  • DNPH1 is a crucial regulator of angiogenesis and YAP1 activity in HER2-driven mammary tumors.
  • DNPH1 represents a promising therapeutic target for various cancers.
Keywords:
CancerCell biology

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