Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blinding01:11

Blinding

4.0K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Completeness of EMERGE guideline reporting in observational studies of PCSK9 inhibitor medication adherence: a study within a systematic review.

JBI evidence synthesis·2026
Same author

Implementing Digital Respiratory Technologies for People With Respiratory Conditions: Scoping Review.

Journal of medical Internet research·2026
Same author

Hair analysis of formoterol as a novel tool to assess long-term inhalation medication adherence: Data from the TRICOLON trial.

British journal of clinical pharmacology·2026
Same author

Development and Psychometric Evaluation of a Novel Medication Adherence Scale for Patients with Chronic Diseases in Low- and Middle-Income Countries.

Patient preference and adherence·2026
Same author

Exploring collaboration preferences of health care professionals and patients regarding treatment decision making in severe asthma: a qualitative study in The Netherlands.

BMJ open·2026
Same author

Long-Term Adherence to Elexacaftor/Tezacaftor/Ivacaftor in People with Cystic Fibrosis.

Pulmonary therapy·2026
Same journal

Determinants of Family Members' Willingness to Donate Organs in Intensive Care Units: A Cross-Sectional Study.

Patient preference and adherence·2026
Same journal

Symptom Clusters and Quality of Life in Cervical Cancer Patients During the Perioperative Period: A Longitudinal Study.

Patient preference and adherence·2026
Same journal

Development and Validation of the Behavioral Determinants of Deprescribing Questionnaire (BDDQ).

Patient preference and adherence·2026
Same journal

Facilitating and Hindering Factors in Discharge Preparation During the Hospital-to-Home Transition Period for Newly Diagnosed Tuberculosis Patients: A Qualitative Study.

Patient preference and adherence·2026
Same journal

Exploring Information Needs and Perspectives on a Patient Decision Aid for Biologic Therapy: A Qualitative Interview Study Among Individuals with Rheumatoid Arthritis.

Patient preference and adherence·2026
Same journal

The Need to Feel Safe: Older Adults' and Family Caregivers' Perspectives on Safe and Person-Centered Medication Management in Home Nursing Care.

Patient preference and adherence·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

Iterative Development of an Innovative Smartphone-Based Dietary Assessment Tool: Traqq
04:54

Iterative Development of an Innovative Smartphone-Based Dietary Assessment Tool: Traqq

Published on: March 19, 2021

5.4K

Smart Blister System with and without Mobile App Support: A Randomized Controlled Usability Trial.

Amber A Eikholt1, Amy H Y Chan2, Job F M Van Boven1,3

  • 1Department of Clinical Pharmacy & Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Patient Preference and Adherence
|March 18, 2026
PubMed
Summary
This summary is machine-generated.

Smart pill packaging improves medication adherence, especially with a mobile app. This technology offers a feasible solution for better long-term disease management and patient support.

Keywords:
digital healthmHealthmedication adherencemobile appsmart packagingusability

More Related Videos

An Application for Pairing with Wearable Devices to Monitor Personal Health Status
06:58

An Application for Pairing with Wearable Devices to Monitor Personal Health Status

Published on: February 3, 2022

3.5K
Evaluation of a Smartphone-based Human Activity Recognition System in a Daily Living Environment
06:49

Evaluation of a Smartphone-based Human Activity Recognition System in a Daily Living Environment

Published on: December 11, 2015

9.4K

Related Experiment Videos

Last Updated: Mar 19, 2026

Iterative Development of an Innovative Smartphone-Based Dietary Assessment Tool: Traqq
04:54

Iterative Development of an Innovative Smartphone-Based Dietary Assessment Tool: Traqq

Published on: March 19, 2021

5.4K
An Application for Pairing with Wearable Devices to Monitor Personal Health Status
06:58

An Application for Pairing with Wearable Devices to Monitor Personal Health Status

Published on: February 3, 2022

3.5K
Evaluation of a Smartphone-based Human Activity Recognition System in a Daily Living Environment
06:49

Evaluation of a Smartphone-based Human Activity Recognition System in a Daily Living Environment

Published on: December 11, 2015

9.4K

Area of Science:

  • Digital Health
  • Medication Adherence Technology
  • Health Informatics

Background:

  • Medication non-adherence is a significant obstacle to effective chronic disease management.
  • Smart packaging offers innovative digital solutions for monitoring and improving patient adherence.
  • Previous research indicates a need for user-friendly adherence monitoring tools.

Purpose of the Study:

  • To evaluate the usability and feasibility of a smart blister pack (Cerepak®) for medication adherence monitoring.
  • To compare adherence monitoring with and without a companion mobile application (MEMS® Mobile).
  • To assess user experience and identify barriers and facilitators for smart packaging adoption.

Main Methods:

  • A randomized controlled trial involving 36 healthy adults over eight weeks.
  • Participants used the smart blister pack with (intervention) or without (control) a mobile app, simulating twice-daily medication intake.
  • Usability was measured using the System Usability Scale (SUS) and user experience surveys, supplemented by semi-structured interviews and electronic/pill count adherence data.

Main Results:

  • The intervention group using the smart blister pack with the mobile app reported significantly higher usability scores (median SUS: 80.0) compared to the control group (67.5; p = 0.0007).
  • Participants found the app's features beneficial for structure, motivation, and ease of use, despite some technical challenges.
  • Electronic adherence rates were 91.7% (app group) vs. 86.2% (non-app group), and pill count adherence was 96.4% vs. 88.0%, respectively, with no statistically significant difference observed between groups.

Conclusions:

  • The smart blister pack, especially when combined with a mobile app, demonstrates high usability and feasibility for daily medication management and adherence tracking.
  • Findings support the potential of this smart packaging technology for improving medication adherence in clinical settings.
  • Further research in patient populations and long-term implementation studies is warranted to validate these promising results.