Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

11.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
11.1K
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.3K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.3K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

520
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
520
Blinding01:11

Blinding

4.0K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
4.0K
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

1.4K
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
1.4K
Randomized Experiments01:13

Randomized Experiments

9.3K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of emergency physicians and artificial intelligence models in pneumothorax detection: A multi-reader retrospective study.

Medicine·2026
Same author

Disparities in Burns Research Authorship in Burn-Specific Journals: Evidence from Low- and Middle-Income Countries.

Journal of burn care & research : official publication of the American Burn Association·2026
Same author

Evaluation of diuretic therapy response in patients with pulmonary edema in the emergency department using the Reverse-FALLS protocol: A prospective observational study.

Medicine·2026
Same author

Management of postpartum rectus diastasis in primary care.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026
Same author

Management and outcomes of acute hand and wrist infections in low- and middle-income countries : a systematic review and meta-analysis.

Bone & joint open·2026
Same author

Implant Pocket Plane Selection in Primary Breast Augmentation: A Meta-Analysis and Systematic Review of Complication Profiles.

Aesthetic plastic surgery·2026
Same journal

Correction to: Global Insights Into Confidence and Self-Perception in Aesthetic Medicine: A 15-Country Survey Analysis.

Aesthetic surgery journal. Open forum·2026
Same journal

Toward Successful International Pooling of Breast Implant Registry Data: The Role of Dataset Uniformity.

Aesthetic surgery journal. Open forum·2026
Same journal

Wrinkles in Time: Uncovering the Early History of Cosmetic Plastic Surgery (1850-1890).

Aesthetic surgery journal. Open forum·2026
Same journal

The Brazilian Butt Lift: An Analysis of Top-Rated Content on the Social Media Platform TikTok.

Aesthetic surgery journal. Open forum·2026
Same journal

Helium Plasma Radiofrequency for Aesthetic Subdermal Treatment: A Systematic Review and Meta-Analysis.

Aesthetic surgery journal. Open forum·2026
Same journal

A Comprehensive Bibliometric Analysis of Global Research Trends in Hair Loss Treatment: Key Contributions, Emerging Hotspots, and Future Directions.

Aesthetic surgery journal. Open forum·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.3K

Facelift Randomized Controlled Trials Compliance With CONSORT Checklist: A Systematic Review.

Yousif F Yousif, Wameth Alaa Jamel, Rocio Perez H

    Aesthetic Surgery Journal. Open Forum
    |March 18, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Randomized controlled trials (RCTs) in facelift surgery have poor reporting quality, impacting evidence for facial rejuvenation. Improving trial transparency through pre-registration and protocol publication is crucial for reliable results.

    More Related Videos

    A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
    04:53

    A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

    Published on: September 20, 2019

    11.4K
    Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
    08:36

    Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

    Published on: April 19, 2024

    1.3K

    Related Experiment Videos

    Last Updated: Mar 19, 2026

    E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
    06:28

    E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

    Published on: August 1, 2019

    9.3K
    A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
    04:53

    A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

    Published on: September 20, 2019

    11.4K
    Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
    08:36

    Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

    Published on: April 19, 2024

    1.3K

    Area of Science:

    • Plastic Surgery
    • Evidence-Based Medicine
    • Clinical Trial Methodology

    Background:

    • Randomized controlled trials (RCTs) in facelift surgery are limited and inconsistently reported.
    • Transparent and reproducible methods are essential for evaluating facelift surgery efficacy and safety.

    Purpose of the Study:

    • To assess the methodological quality and reporting standards of facelift RCTs.
    • To identify adherence patterns and areas for improvement using Consolidated Standards of Reporting Trials (CONSORT) and CONSORT-NPT guidelines.

    Main Methods:

    • A PRISMA-guided systematic review of facelift RCTs was conducted.
    • Methodological quality was assessed using CONSORT 2010/CONSORT-NPT 2017 checklists.
    • Risk of bias and evidence quality were evaluated using Cochrane RoB 2.0 and GRADE.

    Main Results:

    • Ten RCTs (n=457) were included, with mean CONSORT adherence of 56%.
    • High adherence was noted for intervention description and statistical analysis, but poor for trial registration and protocol publication.
    • Only 3 trials had low risk of bias, with largely low-moderate GRADE certainty.

    Conclusions:

    • Facelift RCTs exhibit variable and suboptimal reporting, weakening the evidence base for facial rejuvenation.
    • Enhancing trial quality necessitates pre-registration, protocol publication, validated outcomes, and CONSORT adherence.
    • Standardized reporting and minimum datasets are recommended to strengthen evidence in facial rejuvenation surgery.