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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
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Addressing challenges along the 'access cascade' for new TB regimens.
J Servello1, P de Colombani1, L Dall'Olio1
1Centre for Multidisciplinary Research in Health Science, Universita' di Milano, Milan, Italy.
IJTLD Open
|March 18, 2026
Summary
New tuberculosis (TB) treatments are advancing. This review proposes an
Area of Science:
- Drug development and infectious diseases.
- Global health policy and access to medicines.
- Clinical trial consortia and regulatory affairs.
Background:
- Multiple novel chemical entities are progressing through the tuberculosis (TB) drug development pipeline.
- There is a critical need to ensure timely and equitable access to new TB treatments.
- The UNITE4TB consortium is a global effort focused on developing new TB drugs and regimens.
Purpose of the Study:
- To inform policy discussions on the adoption of new TB treatments.
- To identify and address potential bottlenecks in accessing new TB regimens.
- To propose actionable recommendations for stakeholders to facilitate equitable global access.
Main Methods:
- Analysis of stakeholder engagement within the UNITE4TB consortium.
- Review of outcomes from a UNITE4TB Annual Meeting 2024 session with diverse stakeholder representation.
- Comprehensive literature review on TB drug access and policy.
Main Results:
- A proposed 'access cascade' model outlining the stages from R&D to clinical care.
- Identification of potential bottlenecks hindering equitable global access to new TB regimens.
- Development of stakeholder-specific recommendations to overcome access barriers.
Conclusions:
- Addressing bottlenecks in the access cascade is crucial for successful TB treatment adoption.
- Collaborative action among pharmaceutical, clinical, research, regulatory, oversight, and advocacy groups is essential.
- Proactive strategies are needed to ensure new TB regimens reach all populations equitably and rapidly.
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