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Laminins are the Adhesive Proteins of Basal Lamina

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Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...

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Related Experiment Video

Updated: Mar 19, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Lamins' role in osteosarcoma.

Giulia Bagnato^1,2, Barbara Peruzzi^2,3

¹DAHFMO - Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.

Frontiers in Cell and Developmental Biology

|March 18, 2026

Summary

This summary is machine-generated.

This review explores the role of lamins in osteosarcoma (OS), a rare bone cancer. Lamins are key nuclear proteins involved in mechanotransduction and bone cell differentiation, crucial for understanding OS biology.

Keywords:

bone tissue lamins mechanotransduction nuclear envelope osteosarcoma

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Area of Science:

Biochemistry
Cell Biology
Oncology

Background:

Osteosarcoma (OS) is an aggressive bone cancer predominantly affecting long bones, with open questions regarding its biology and treatment efficacy.
Mechanotransduction, the process by which cells convert mechanical stimuli into biochemical signals, is increasingly recognized as a critical regulator of cellular functions.
The cell nucleus, particularly the nuclear envelope and its components like lamins, plays an active role in mechanosensing and mechanotransduction within bone tissue.

Purpose of the Study:

To review the current understanding of lamins' role in osteosarcoma (OS) biology.
To highlight the involvement of nuclear proteins in mechanotransduction within bone cancer.
To discuss the potential implications of lamins in bone cell differentiation and OS pathogenesis.

Main Methods:

Literature review of recent research on osteosarcoma.
Analysis of studies focusing on mechanotransduction in bone cells.
Examination of the function of nuclear lamins in cellular processes.

Main Results:

Lamins are essential components of the inner nuclear membrane.
Lamins are pivotal in mechanotransduction and bone cell differentiation.
Emerging evidence points to the nucleus as an active participant in bone tissue mechanosensing.

Conclusions:

Lamins are integral to the nucleus's role in mechanotransduction.
Understanding lamins' function in OS biology may offer new therapeutic avenues.
Further research into lamins' involvement in bone cancer is warranted.