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Updated: Mar 19, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Reflections on prevention and treatment of post-thyroidectomy hypoparathyroidism: current management approaches and
Jia Li1,2, Zilai Hu2, Zhiyuan Ma2
1Department of Hepatobiliary Pancreatic and Thyroid Surgery, Department of General Surgery, People's Hospital of Zunyi City Bozhou District, Zunyi, China.
Abstract:
Postoperative hypoparathyroidism (hypoPT) is one of the predominant and severe complications of thyroid surgery. This condition manifests as suboptimal circulatory levels of parathyroid hormone (PTH), engendering multifaceted systemic perturbations. This comprehensive review elucidates the underlying pathophysiological mechanisms and clinical presentations associated with hypoparathyroidism. Moreover, methodologies for the precise recognition and preservation (naked eye, near-infrared autofluorescence, indocyanine green, carbon nanoparticles, and mitoxantrone hydrochloride) of the parathyroid gland during thyroid surgery have been explored, along with recent therapeutic innovations (palopegteriparatide and parathyroid organoids). Finally, this review prospects and interventions via organoids are contemplated. The aim of the literature is to recapitulate the knowledge and the gaps in this field, increasing awareness of postoperative hypoparathyroidism, and improve the prognosis for patients afflicted with hypoparathyroidism.
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