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N‑Alkyl and N‑Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally

Rohan R Merchant1, Natalia Chernyak1, Jovan A Lopez1

  • 1Department of Discovery Chemistry, Merck & Co., Inc., South San Francisco, California 94080, United States.

ACS Medicinal Chemistry Letters
|March 18, 2026
PubMed

Keywords:
Fsp3H-BondLead OptimizationStructure-Based Drug Design (SBDD)TDITorsional AnglespKal

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