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Updated: Mar 19, 2026

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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Novel Epidermal Growth Factor Receptor (EGFR) Exon20 Insertion-Selective Inhibitors for Lung Cancer Therapy

Yanwei Jiang1, Steven H Liang1,2

  • 1Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.

ACS Medicinal Chemistry Letters
|March 18, 2026
PubMed

Insights

This patent reveals new prop-2-ynamide compounds that inhibit epidermal growth factor receptor (EGFR) mutations. These inhibitors show promise for treating non-small cell lung cancer (NSCLC) and other cancers.

Area of Science:

  • Medicinal Chemistry
  • Oncology
  • Molecular Biology

Background:

  • Epidermal growth factor receptor (EGFR) mutations, particularly exon20 insertion mutations, are key drivers in non-small cell lung cancer (NSCLC).
  • Targeting these specific mutations presents a therapeutic challenge due to resistance mechanisms and lack of effective inhibitors.

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