Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.4K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.4K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

960
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
960
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

784
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
784
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

636
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
636
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

1.1K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K
Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spontaneous coronary artery dissection cohort study: A nationwide Tunisian series.

La Tunisie medicale·2026
Same author

Percutaneous mitral commissurotomy in pregnant women: Immediate and long-term outcomes.

La Tunisie medicale·2026
Same author

Percutaneous coronary intervention of chronic total occlusion: A 5-year monocentric experience [cite: 62].

La Tunisie medicale·2026
Same author

Google Sites as an innovative e-learning tool for methodical electrocardiogram interpretation: a randomized study among pre-graduate students at the Faculty of Medicine of Tunis.

La Tunisie medicale·2026
Same author

Outcomes after Balloon Pulmonary Valvuloplasty for Critical Pulmonary Stenosis: A Tunisian reference center experience.

La Tunisie medicale·2026
Same author

Impact of hypnosis during coronarography.

La Tunisie medicale·2026

Related Experiment Video

Updated: Mar 19, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.5K

Cardiac Phenotypes and Endophenotypes in Schizophrenia : A systematic Review.

Amine Larnaout1, Zeynab Jebberi2, Mohamed Salah Hamdi3

  • 1University of Tunis El Manar, Faculty of Medicine of Tunis, 1002, Razi Hospital, Department of Psychiatry D. Research Laboratory LR18SP03 : Maladies Neurodégénératives et Troubles Psychiatriques, 2010, Manouba, Tunisia.

La Tunisie Medicale
|March 18, 2026
PubMed
Summary

Autonomic dysfunction, specifically impaired heart rate variability (HRV), is the only cardiac abnormality meeting endophenotype criteria in schizophrenia. Further research is needed to clarify the mental and heart disease link.

Keywords:
Schizophreniaanomaliesendophenotypesheartphenotypes

More Related Videos

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

7.1K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.8K

Related Experiment Videos

Last Updated: Mar 19, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.5K
Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

7.1K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.8K

Area of Science:

  • Cardiology
  • Psychiatry
  • Genetics

Background:

  • Schizophrenia is a multisystemic disorder with frequent cardiac anomalies.
  • Cardiac issues include autonomic, electrophysiological, and structural heart abnormalities.
  • The distinction between cardiac phenotypes and endophenotypes in schizophrenia is unclear.

Purpose of the Study:

  • To review clinical, neurobiological, and genetic evidence of cardiac alterations in schizophrenia.
  • To evaluate the potential of these cardiac anomalies as endophenotypes for schizophrenia.

Main Methods:

  • Systematic review of existing literature.
  • Synthesis of clinical, neurobiological, and genetic data.
  • Assessment of cardiac anomalies against endophenotype criteria.

Main Results:

  • Autonomic dysfunction, characterized by reduced heart rate variability (HRV) and parasympathetic impairment, is the most consistent cardiac phenotype.
  • Impaired HRV meets the criteria for an endophenotype in schizophrenia.
  • Electrophysiological and structural anomalies show genetic links but lack sufficient evidence to be endophenotypes.

Conclusions:

  • Autonomic dysfunction, specifically HRV impairment, is the sole cardiac anomaly fulfilling endophenotype criteria in schizophrenia.
  • Observational nature of most studies limits conclusion robustness.
  • Future heritability and multi-omic studies are essential to understand the pathogenomic link between schizophrenia and heart disease.