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Updated: Mar 19, 2026

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
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Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

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Inhibition of prolyl-tRNA synthetase and efflux pumps as a dual-targeting strategy against multidrug-resistant

Cristiane Tambascia1, Jaqueline Cristina Silva1, Barbara Carvalho Dos Reis1,2

  • 1Brazilian Biosciences National Laboratory (LNBio), Brazilian Centre for Research in Energy and Materials (CNPEM), Campinas, SP, Brazil.

Journal of Enzyme Inhibition and Medicinal Chemistry
|March 18, 2026
PubMed

Keywords:
Klebsiella pneumoniaeaminoacyl-tRNA synthetase inhibitorsantimicrobial resistanceefflux pump inhibitorsgram-negative bacteria

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