Related Experiment Video For Dynamic CA125 increase
Updated: Mar 20, 2026
Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
Published on: July 18, 2016
The diagnostic value of [18F]F-NOTA-FAPI PET/CT in suspected recurrent ovarian cancer with CA125 dynamic increase
Shuai Liu1,2,3,4, Zheng Feng5,2, Yangjun Wu5,2
1Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, No.270 Dong'an Road, Xuhui district, Shanghai, 200032, China.
Abstract:
PURPOSE: We aimed to explore the diagnostic value of [18F]F-NOTA-FAPI-FUSCC-07 ([18F]F-NOTA-FAPI) PET/CT in suspected recurrence ovarian cancer with CA125 dynamic rising but negative conventional imaging findings. METHODS: Forty-one suspected recurrent ovarian cancers who experienced [18F]F-NOTA-FAPI PET/CT for further diagnosis because of continuously rising CA125 value but negative conventional imaging (CT, MR or [18F]FDG PET/CT) findings were enrolled from June 2022 to January 2024. All conventional and [18F]F-FAPI PET/CT scans were performed in sequence within one week. Clinical characteristics, treatment data, [18F]F-NOTA-FAPI PET/CT findings, and survival outcomes were recorded. Differences in [18F]F-NOTA-FAPI PET/CT parameters across CA125 levels were analyzed using the Mann-Whitney U test. RESULTS: [18F]F-NOTA-FAPI PET/CT was positive in 34 patients (82.93%). Lesions were primarily peritoneal (85.29%), followed by lymph nodes (23.53%), stomach (8.82%), and small intestine (2.94%). Prior to imaging, median CA125 level was 51.90 (9.12–1586.00) U/mL, with a rising rate of 0.45 (0.02–44.42) U/mL/day and a doubling time of 56.28 (6.18-613.14) days. Detection rates were higher in the high-CA125 group (positive: 88.24%, negative: 11.76%) compared to the low-CA125 group (positive: 79.17%, negative: 20.83%). Notably, diagnostic performance was superior in patients with CA125 levels between 35 and 70 U/mL. Among 7 FAPI-negative patients, 3 were true-negative and 4 were false-negative. Disease relapse occurred in 30 patients (73.17%) after treatment, with a median PFS of 11.99 months (0-29.2). PFS differed significantly between FAPI-positive and FAPI-negative groups (p = 0.016). CONCLUSIONS: [18F]F-NOTA-FAPI PET/CT demonstrated superior diagnostic performance in ovarian cancer patients with rising CA125 levels and negative conventional imaging findings, particularly in those with CA125 levels between 35 and 70 U/mL.
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