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Iatrogenic Injury Recapitulated: Electroexcision Technique for Urethral Stricture Modeling in Rats
Published on: October 11, 2024
Abstract:
The article "IRF9 Affects the TNF-Induced Phenotype of Rheumatoid-Arthritis Fibroblast-Like Synoviocytes via Regulation of the SIRT-1/NF-κB Signaling Pathway" [Cells Tissues Organs. 2020;209(2-3):110-119; https://doi.org/10.1159/000508405] by Fan Jiang, Hong-Yi Zhou, Li-Fang Zhou, Wei Zeng, and Li-Han Zhao has been retracted by the Publisher and the Editors.After publication of this article, concerns were raised about the integrity of the data presented in Figure 1. Specifically, panels in Figure 1c had previously been published by different author groups representing different experimental conditions.Figure 1c "control" panel is the same as Figure 3b panel "Anti-miR-C FITC-A" in [1], Figure 3b panel "NC siRNA" [2], and Figure 3a panel "SNORD44" in [3].Figure 1c "TNF" panel is the same as Figure 3a panel "Anti-miR-C" in [1].Figure 1c "TNF + sh-Ctrl" panel is the same as Figure 3a panel "Anti-miR-186" in [1] and Figure 3b panel "empty vector" in [3].Figure 1c "sh-IRF9" panel is the same as Figure 3b panel "miR-C FITC-A" in [1] and Figure 3b panel "blank" in [2].Figure 1c "TNF + sh-IRF9" panel is the same as Figure 3d panel "Anti-miR-186 FITC-A" in [1].Figure 1c "TNF + sh-SIRT1" panel is the same as Figure 3a panel "miR-C FITC-A" in [1] and Figure 3a panel "control" in [3].Figure 1c "TNF + sh-IRF9 + sh-SIRT1" panel is the same as Figure 3a panel "miR-186 FITC-A" in [1] and Figure 3a panel "empty vector" in [3].The authors did not respond to requests to comment on the concerns and provide the raw data within the given timeframe despite multiple attempts of contact. The matter was raised to the corresponding author's institution who did not respond to our request for an investigation. Given the severity of the concerns raised, this article is being retracted. The authors have not responded to our correspondence regarding this retraction despite multiple attempts of contact.
Insights
This study on rheumatoid arthritis fibroblast-like synoviocytes has been retracted due to data integrity concerns in Figure 1. The publisher retracted the article after authors failed to respond to data verification requests.
Area of Science:
- Immunology
- Cell Biology
- Rheumatology
Background:
- Rheumatoid arthritis (RA) is characterized by inflammation of the synovium.
- Fibroblast-like synoviocytes (FLS) play a key role in RA pathogenesis.
- Tumor necrosis factor (TNF) is a major pro-inflammatory cytokine in RA.
Purpose of the Study:
- To investigate the role of Interferon Regulatory Factor 9 (IRF9) in TNF-induced RA FLS phenotype.
- To elucidate the involvement of the SIRT-1/NF-κB signaling pathway in this process.
Main Methods:
- The study utilized cell culture of RA FLS.
- Experiments involved stimulation with TNF and manipulation of IRF9, SIRT-1, and NF-κB signaling.
- Data analysis included assessing cellular phenotypes and pathway activation.
Main Results:
- Concerns were raised regarding the integrity of data presented in Figure 1.
- Specific panels in Figure 1c were found to be identical to data published by other groups under different experimental conditions.
- The authors did not provide raw data or respond to requests for clarification.
Conclusions:
- The article has been retracted by the publisher and editors due to significant data integrity issues.
- The lack of response from the authors and their institution prevented verification of the findings.
- Retraction underscores the importance of data reproducibility and ethical research practices.
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