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Effects of Bariatric Surgery in Individuals with PTEN Hamartoma Tumor Syndrome: A Systematic Review
Isela N Oceguera1,2, Wah Yang3, Chetan Parmar4,5,6
1University of Guadalajara, Health Sciences University Center, Guadalajara, Mexico.
Introduction:
The aim of this systematic review was to provide an overview of the literature on the effects of bariatric surgery in patients with obesity and phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) diagnosis.
Methods:
A systematic literature search was conducted using the search word PHTS and Bariatric Surgery, modified for each database. Studies were included if they investigated the effects of bariatric surgery in patients with bariatric surgery.
Results:
Two studies were included with a methodological quality ranging from poor to good. Both studies were case reports in young females (<35 years old), and massive effects on weight loss and HbA1c levels were seen. Bariatric surgery in obese patients with PHTS diagnosis results in significant decrease in weight and complete remission of diabetes mellitus type 2. The effects on thyroid hormones, lipid levels, renal function, and psychological factors after bariatric surgery in PHTS remain unexplored.
Conclusion:
More research is needed to fully understand how bariatric surgery can take part of the preventative treatment options for PHTS patients with obesity.
