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Related Concept Videos

Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

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Related Experiment Video

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Usability and Acceptance Testing of an Electronic Patient-Reported Outcome Symptom Monitoring System for People

Julia Lai-Kwon1,2, Claudia Rutherford3, Stephanie Best4,5

  • 1Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

JMIR Formative Research
|March 18, 2026
PubMed
Summary

This study shows an electronic patient-reported outcome (ePRO) system for monitoring immune-related adverse events (irAEs) is highly usable and accepted by patients, caregivers, and clinicians, improving cancer care. Refinements will address navigation and equity concerns before wider implementation.

Keywords:
acceptancedigital healthelectronic patient-reported outcomesimmune checkpoint inhibitorsimmunotherapypatient-reported outcomessymptom monitoringusability

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Area of Science:

  • Oncology
  • Digital Health
  • Patient Safety

Background:

  • Immune checkpoint inhibitors (ICIs) are crucial in oncology but can cause severe immune-related adverse events (irAEs).
  • Early detection and management of irAEs are vital for patient safety.
  • Electronic patient-reported outcome (ePRO) systems can aid in timely irAE monitoring, but formal usability testing is lacking.

Purpose of the Study:

  • To assess the usability and acceptance of a co-designed ePRO symptom monitoring prototype for irAEs.
  • To evaluate the prototype's integration within the Epic electronic medical record.
  • To identify areas for improvement in the ePRO system for routine cancer care.

Main Methods:

  • Usability and acceptance testing of an ePRO prototype involving patients, caregivers, and clinicians (oncologists, nurse specialists).
  • Digital literacy assessments (MDPQ-16, CPQ-12), System Usability Scale (SUS), and Unified Theory of Acceptance and Use of Technology (UTAUT) questionnaires were used.
  • Semistructured interviews captured qualitative feedback on user experience and system integration.

Main Results:

  • The ePRO prototype demonstrated high usability (SUS scores: 77.5%-94.4%) and strong acceptance (UTAUT scores: 4.09-4.63) across all participant groups.
  • Patients and caregivers reported ease of navigation and reporting, while clinicians found side effect capture efficient.
  • Identified areas for improvement include survey navigation, data visualization, alert management, and addressing digital equity concerns.

Conclusions:

  • The co-designed ePRO system shows significant promise for monitoring irAEs in oncology, with high usability and acceptance.
  • Addressing identified limitations in navigation, data display, equity, and workload is crucial for successful implementation.
  • Rigorous usability and acceptance testing are essential for optimizing ePRO systems in routine cancer care.