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Bioinspired Integration of Cellular Microlattices and Asymmetric Re-Entrant Microstructures for Directional Capillary

Shuheng Li1,2, Lihao Liu1,2, Yuning Zhou1,2

  • 1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, China.

ACS Applied Materials & Interfaces
|March 18, 2026
PubMed
Summary

This study introduces a 3D microreaction platform using bioinspired structures for efficient, power-free liquid transport and controlled reaction volumes. This innovation advances microfluidics for chemical and biological applications.

Keywords:
asymmetric re-entrant microstructurescellular microlatticesmicrofluidicsmicroreactionunidirectional capillary

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Area of Science:

  • Microfluidics and Bioinspired Engineering
  • Materials Science and Engineering
  • Chemical Engineering

Background:

  • Self-propelled directional liquid transport offers power-free reagent delivery for microreaction systems.
  • Current fluidic manipulation is limited to 2D surfaces, restricting scalability and control.
  • Bioinspired asymmetric re-entrant microstructures enhance capillary forces for fluid manipulation.

Purpose of the Study:

  • To develop an open microreaction platform integrating cellular microlattices and asymmetric re-entrant microstructures.
  • To achieve synergistic unidirectional liquid transport and programmable reaction volume control.
  • To overcome the limitations of 2D fluidic systems in microreaction applications.

Main Methods:

  • Fabrication of 3D microarchitectures using a programmable layer-reduction 3D printing strategy.
  • Integration of cellular microlattices with asymmetric re-entrant microstructures.
  • Characterization of capillary performance and demonstration of liquid mixing and chemical reactions.

Main Results:

  • The fabricated microarchitectures exhibited high fidelity and outstanding capillary performance.
  • Achieved an ethanol rise height of 39.9 mm and unidirectional transport of 40.0 mm.
  • Successfully demonstrated physical liquid mixing and a phenolphthalein-based acid-base neutralization reaction.

Conclusions:

  • The bioinspired 3D microreaction platform enables volume-controlled, directional capillary transport.
  • This strategy overcomes 2D limitations, offering enhanced scalability and controllability for microreaction systems.
  • The platform holds strong potential for advanced chemical and biological applications requiring precise fluid handling.