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Updated: Mar 20, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Two new polyketide derivatives isolated from the mangrove-derived fungus Aspergillus sp. GXNU 2Y10
Fan He1, Wenjun Li1, Youquan Wei1
1State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.
Abstract:
Two new polyketide compounds, aspmacrphins C (1) and aspmacrphins D (2), were isolated from the secondary metabolites of the mangrove endophytic fungus Aspergillus sp. GXNU 2Y-10. The structures of 1 and 2 were elucidated on the basis of detailed nuclear magnetic resonance (NMR) and high-resolution electrospray ionisation mass spectrometry (HRESIMS) data analysis. Remarkably, these two polyketide compounds displayed significant activity against Diaphorina citri, with mortality rates of 85.3% and 70.4% observed at a dose of 1000 mg/kg, respectively.
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