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From Prognosis to Action: Circulating Tumor DNA and the Next Phase of Risk Stratification in Triple-Negative Breast

Bryan P Schneider1, Daniel G Stover2

  • 1Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|March 18, 2026
PubMed
Abstract

No abstract available in PubMed .

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...