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Updated: Mar 20, 2026
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
Sigmoid wall thickness correlates with fecal calprotectin during irritable bowel syndrome exacerbation
Tarek Mazzawi1, Sara Haj Ali2, Kim Nylund3
1Department of Internal Medicine, Faculty of Medicine, Al-Balqa Applied University, Salt. tarek.mazzawi@bau.edu.jo.
Aim:
Patients with diarrhea-predominant irritable bowel syndrome (IBS-D) who present with symptom exacerbation [defined by a high IBS-Symptom Severity Scale (IBS-SSS)] may have increased fecal calprotectin (FC). Intestinal ultrasound (IUS) is used to measure bowel wall thickness (BWT). The aim of our study was to measure BWT in IBS-D patients, ulcerative colitis (UC) and healthy controls (HC), and compare BWT, IBS-SSS score, and FC level.
Material And Method:
Patients with IBS-D and symptom exacerbation (n=100), active UC (n=25), and HC (n=30) were included. FC was measured in all groups. IBS-D patients with an IBS-SSS score >75 and FC level >50 µg/g underwent IUS and colonoscopy.
Results:
Patients with IBS-D had a (mean±SEM) IBS-SSS score of 268±11, FC level of 260±46 µg/g, and a normal colonoscopy. IUS showed a significant difference (p<0.0001) between sigmoid BWT for IBS-D (3.16±0.09 mm) and HC (1.6±0.12 mm). Color Doppler signals were also absent. A significant correlation between sigmoid BWT and FC level (r=0.48, p=0.0012) was found in patients with IBS-D.
Conclusion:
Compared to HC, sigmoid BWT was significantly increased in IBS-D patients with symptom exacerbation. Sigmoid BWT correlates significantly with FC levels during IBS-D symptom exacerbation.
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