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Design and structural optimization of lappaconitine derivatives as Nav1.7 inhibitors with improved analgesic efficacy

Long Wang1, Jiaqi Zou2, Xiaolong Ma2

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, 201203, China.

European Journal of Medicinal Chemistry
|March 18, 2026
PubMed

Keywords:
AnalgesicDorsal root ganglionLappaconitineLethalityNav1.7Postoperative pain

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