Related Experiment Video
Updated: Mar 20, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Suboptimal therapeutic responses associated with semaglutide in type 2 diabetes and obesity: A meta-analysis of
Donghyun Ko1, Do Han Kim2, Faith Xin Ning Tan3
1Department of Medicine, Bridgeport Hospital, Yale New Haven Health, Bridgeport, CT, USA.
Abstract:
Semaglutide has emerged as a leading therapy for metabolic disorders, with robust evidence supporting its role in treating obesity and type 2 diabetes while reducing cardiovascular and renal risks. However, limited data exist on the proportion of patients who have suboptimal therapeutic responses or discontinue treatment due to adverse events. We present an analysis including 33 randomized controlled trials (RCTs) comprising 21,023 participants. Across included trials of patients with and without type 2 diabetes, 33.4% and 65.1% of participants did not achieve ≥5% or ≥10% total body weight reduction, respectively. Stratified analyses demonstrated higher rates of suboptimal outcomes among individuals with type 2 diabetes mellitus (T2DM), with up to 79.8% not achieving ≥10% weight loss, compared to 30.1% among individuals without T2DM. While semaglutide is effective in many patients, a substantial subset of patients has suboptimal weight or glycemic improvements or discontinues therapy. This study was registered with PROSPERO (CRD420251086132).
Related Concept Videos
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Diabetes Mellitus: Type 2 and Gestational
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Hypoglycemia and Glucagon

