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Updated: Mar 20, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
Published on: October 4, 2024
Cornus officinalis Siebold & Zucc. ethanol extract alleviates primary dysmenorrhea via anti-inflammatory and
Yan Xu1, Jingxi Zhang1, Mengyue Zhang1
1Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, College of Food Science and Technology, Modern Biochemistry Experimental Center, Zhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain Health, Guangdong Ocean University, Zhanjiang 524088, China.
Abstract:
This study investigated the effects and mechanisms of Cornus officinalis Siebold & Zucc. ethanol extract (COEE) on primary dysmenorrhea (PD). COEE administration dose-dependently reduced writhing times, prolonged writhing latency, decreased uterine prostaglandin F2α (PGF2α) levels and pro-inflammatory mediators, and improved histopathological signs of uterine inflammation. Furthermore, COEE suppressed the activation of the TLR4/MyD88/NF-κB/NLRP3 signaling axis. In ex vivo experiments, COEE inhibited spontaneous and agonist-induced uterine contractions, attenuated CaCl2-induced contractile recovery, and reduced Bay K 8644 evoked Ca2+-mediated contractions. Collectively, our findings suggested that COEE alleviates PD by attenuating uterine inflammation and abnormal calcium-dependent contractions, supporting its potential use as a functional food source for managing PD.
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