Related Experiment Video

Updated: Mar 20, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

9.5K

Rotavirus-associated disease burden and clinical severity in vaccine-naive Chinese infants: A synthesized Bayesian

Di Liu1, Bing Zhang1, Changhong Shi1

  • 1School of Public Health, Guangzhou Medical University, Guangzhou, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|March 18, 2026
PubMed

Insights

Rotavirus (RV) infections are common in Chinese infants but mostly mild. Current surveillance misses many cases, highlighting the need for RV vaccination in China.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • Rotavirus (RV) is a primary cause of severe diarrhea in children globally.
  • Limited data exists on the true burden and clinical severity of natural rotavirus infection in China.
  • Unvaccinated Chinese infants are the focus for understanding RV disease progression.

Purpose of the Study:

  • To estimate the incidence and clinical spectrum of rotavirus infection in unvaccinated Chinese infants.
  • To quantify the burden of rotavirus disease beyond severe or hospitalized cases.
  • To inform rotavirus vaccine policy in China.

Main Methods:

  • Utilized pooled data from placebo arms of rotavirus vaccine clinical trials in China.
  • Employed a six-state burden pyramid model to represent disease progression.
  • Applied a Bayesian framework to estimate transition probabilities and disease metrics.

Main Results:

  • Analyzed data from 11,235 infants, with 20,248 observations.
  • Estimated an annual rotavirus infection rate of 495.8 per 1,000 infants.
  • Reported low progression rates: 10.3% symptomatic, 4.1% severe, 1.5% hospitalized, 0.09% fatal.

Conclusions:

  • Natural rotavirus infection in infants is frequent but often subclinical.
  • Surveillance focusing only on severe or hospitalized cases significantly underestimates rotavirus burden.
  • Findings support the integration of rotavirus vaccines into China's national immunization program.
Abstract

Keywords:
Chinese infantsClinical severityDisease burdenRotavirusVaccine-naive

More Related Videos

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay09:14

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

11.6K
Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

17.5K

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
5
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
5
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
2
Vaccinations01:51

Vaccinations

Overview
53.3K
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
7
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
1