Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

5.8K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.8K
Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

5.6K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
5.6K
Dietary Connections01:23

Dietary Connections

64.5K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
64.5K
Overview of Metabolism01:40

Overview of Metabolism

40.7K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
40.7K
Origin of Cellular Life01:24

Origin of Cellular Life

10
The origin of life on Earth is a complex and enigmatic event rooted in ancient biochemical processes and geological conditions. Experimental evidence supports the hypothesis that life began with the spontaneous formation of organic molecules such as RNA nucleotides, amino acids, and lipids under early Earth conditions. Factors like volcanic activity, intense UV radiation, and a reducing atmosphere without free oxygen likely facilitated these reactions. Hydrothermal vents on the ocean floor are...
10
Respiration Pathways01:26

Respiration Pathways

887
Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
887

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards the construction of a virtual yeast.

Nature·2026
Same author

Protective role of cyanidin-3-O-glucoside in 2-amino-3-methylimidazo[4,5-f]quinoline-induced gastrointestinal injury: focus on oxidative stress, inflammation, intestinal barrier and gut microbiota.

Journal of the science of food and agriculture·2026
Same author

The Potential and Prospects of Marine Drugs in Intervening Nerve-Tumor Crosstalk.

Marine drugs·2026
Same author

MoE-Enhanced Explainable Deep Manifold Transformation for Complex Data Embedding and Visualization.

IEEE transactions on pattern analysis and machine intelligence·2026
Same author

Standardizing microplastic quantification by scanning electron microscopy: Structural performance of filter membranes and implications from bottled drink analysis.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Efficient Inference for Large Reasoning Models: A Survey.

IEEE transactions on pattern analysis and machine intelligence·2026
Same journal

Metabolic control of RNA splicing by polyamines.

Trends in biochemical sciences·2026
Same journal

The role of glycan modifications in health and disease.

Trends in biochemical sciences·2026
Same journal

Strengthening the philosophical basis of graduate science education.

Trends in biochemical sciences·2026
Same journal

CycloPepper learns cyclization sites in therapeutic peptides.

Trends in biochemical sciences·2026
Same journal

Glycosphingolipids in cell identity: Biosynthesis, functions, and emerging tools.

Trends in biochemical sciences·2026
Same journal

Cap in hand: giant viruses, stolen translation, and a road to endosymbiosis?

Trends in biochemical sciences·2026
See all related articles

Related Experiment Video

Updated: Mar 20, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.6K

Artificial intelligence revolutionizes cellular metabolic pathway reconstruction.

Jiangbin Zheng1, Xinyan Xu2, Qirong Yang3

  • 1Westlake University, Hangzhou, China; Zhejiang University, Hangzhou, China; Shanghai Artificial Intelligence Laboratory, Shanghai, China; BioMap Research, Beijing, China.

Trends in Biochemical Sciences
|March 18, 2026
PubMed
Summary
This summary is machine-generated.

Reconstructing cellular metabolic pathways is difficult. This study presents a framework combining retrosynthesis and biological constraints for improved feasibility, enabling better design and optimization of metabolic networks.

Keywords:
AI virtual metabolismartificial intelligencebiological constraintsgenome-scale metabolic modellarge language modelmetabolic pathway reconstruction

More Related Videos

High-Throughput Metabolic Profiling for Model Refinements of Microalgae
11:07

High-Throughput Metabolic Profiling for Model Refinements of Microalgae

Published on: December 4, 2021

4.3K
Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria
08:33

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria

Published on: July 28, 2023

1.1K

Related Experiment Videos

Last Updated: Mar 20, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.6K
High-Throughput Metabolic Profiling for Model Refinements of Microalgae
11:07

High-Throughput Metabolic Profiling for Model Refinements of Microalgae

Published on: December 4, 2021

4.3K
Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria
08:33

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria

Published on: July 28, 2023

1.1K

Area of Science:

  • Synthetic Biology
  • Metabolic Engineering
  • Computational Biology

Background:

  • Cellular metabolic pathway reconstruction is crucial for synthetic biology.
  • Current methods face challenges in ensuring biological feasibility.
  • Accurate pathway reconstruction is essential for designing novel biological functions.

Purpose of the Study:

  • To present a conceptual framework for metabolic pathway reconstruction.
  • To integrate retrosynthetic planning with biological constraints.
  • To enhance the biological feasibility of reconstructed metabolic networks.

Main Methods:

  • Developed a conceptual framework integrating retrosynthetic planning.
  • Incorporated biological constraints into the modeling process.
  • Utilized systems-level and individual-level modeling approaches.

Main Results:

  • The proposed framework enhances the biological feasibility of metabolic pathway reconstruction.
  • The approach facilitates a comprehensive understanding, design, evaluation, and optimization of metabolic networks.
  • Enabled large language model-driven insights into metabolic network engineering.

Conclusions:

  • The integrated framework offers a novel approach to metabolic pathway reconstruction.
  • This method improves the design and optimization of cellular metabolic networks.
  • It holds potential for advancing synthetic biology applications through enhanced biological feasibility.