Baseline Antral Follicle Count Compared to Mature Oocytes Retrieved During Autologous In Vitro Fertilization Cycles

Area of Science:

• Reproductive Medicine
• Infertility Research
• Assisted Reproductive Technologies

Background:

• In vitro fertilization (IVF) is a final option for infertility patients, often leading to unrealistic expectations due to social media information.
• Autologous oocyte retrieval outcomes can vary, impacting patient expectations.

Purpose of the Study:

• To assess the association between baseline antral follicle count (AFC) and mature oocytes retrieved during autologous IVF with intracytoplascialmic sperm injection (ICSI).
• To improve patient counseling by providing better predictions of mature oocyte yield.

Main Methods:

• Retrospective chart review of 362 women aged 18-41 undergoing IVF with ICSI (2015-2022).
• Collected baseline AFC and mature oocytes obtained.
• Utilized univariate and multivariate regression models to determine predictive accuracy (R-squared).

Main Results:

• Baseline AFC predicted 26.7% of mature oocytes retrieved (R-squared = 0.267).
• One mature oocyte was obtained for approximately every four baseline AFC.
• Multivariate models showed only marginal improvement in prediction (R-squared = 0.325); age was a weaker predictor (R-squared = 0.085).

Conclusions:

• A simple, highly accurate model to predict mature oocytes from baseline AFC was not achieved.
• Significant variability exists in oocyte yield prediction, emphasizing the complexity of infertility.
• Findings underscore the need for comprehensive patient counseling regarding expected outcomes and response variations in IVF.