Sleep disorders and sleep behaviors as predictors of neurodegenerative diseases
Taewon Kim1, Daeun Jung2, Kyung Min Kim3,4
1Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, South Korea.
Introduction:
The impact of sleep disorders (SDs) on incident neurodegenerative disease (NDD) risk has not been comprehensively investigated.
Methods:
In the UK Biobank cohort, 30,032 participants with SDs (defined by diagnostic codes) and 147,321 without SDs were included. Cox proportional hazards models assessed associations between SDs and NDD risk. NDD prediction models incorporating SD subtype variables were developed.
Results:
SD was associated with increased NDD risk (hazard ratio [HR]: 1.32, 95% confidence interval: 1.23 to 1.41). This association was observed regardless of treatment status, and several SD subtypes were also associated with increased NDD risk. Sleep behaviors, including difficulty waking and usual daytime napping, were associated with higher NDD risk among individuals with SD. SD subtype variables improved NDD prediction model performance and clinical utility in an external cohort.
Discussion:
SDs and related sleep behaviors were strong predictors of NDD risk, underscoring their potential as targets for early prevention strategies.
Related Concept Videos
REM Sleep Behavior Disorder
RBD is significantly associated with...
Parkinson's Disease: Overview
Sleepwalking and Sleep Talking
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Neural Regulation
Narcolepsy


