Related Experiment Video
Updated: Mar 20, 2026
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
Circadian syndrome (CircS) and cognitive trajectory deterioration in middle-aged and older adults: A national cohort
Jiangping Ma1,2, Nan Chen1,2, Jingxuan Huang1,2
1Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.
Introduction:
Cognitive impairment is a global health challenge. Circadian syndrome (CircS) extends beyond metabolic syndrome to include sleep and mental health, but its long-term impact on cognitive trajectories remains unclear.
Methods:
We analyzed 6218 participants from the China Health and Retirement Longitudinal Study (2011-2018). CircS was defined as ≥4 of 7 components. Cognitive trajectories were identified using latent class growth modeling. Associations were assessed via multinomial logistic regression, and heterogeneous effects via causal forest analysis.
Results:
Three cognitive trajectories were identified: "persistently high" (40.29%), "persistently moderate" (43.78%), and "persistently low" (15.93%). CircS increased odds of "persistently low" global cognitive (adjusted OR = 1.27, 95%CI:1.06-1.52) and episodic memory (OR = 1.28, 95%CI:1.06-1.55) trajectories. Causal forest identified a vulnerable subgroup: younger age, mild anemia (Hb∼95 g/L), and elevated BMI.
Discussion:
CircS is a significant, modifiable risk factor for adverse cognitive trajectories. Screening for CircS could enable early identification and targeted interventions, especially for the identified high-risk subgroup.
More Related Videos
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
12:06Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex
Published on: August 19, 2025
Related Concept Videos
01:30Cognitive Development During Adulthood
02:19Circadian Rhythms and Gene Regulation
02:19Circadian Rhythms and Gene Regulation
01:26Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
01:30Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...