ARIAs are not random: A posterior and border-zone vascular vulnerability model
1Department of Translational Biomedicine and Neuroscience, Neurology Unit, University of Bari Aldo Moro, Bari, Italy.
Abstract
Highlights:
ARIA often shows posterior and watershed predominance, indicating region-specific vascular vulnerability beyond amyloid burden alone. Reduced autoregulatory reserve in posterior territories may predispose to blood-brain-barrier disruption during anti-amyloid therapy. Watershed regions are hemodynamically fragile, lowering the threshold for vasogenic edema or microhemorrhage after amyloid mobilization. ARIA may represent a PRES-like neurovascular decompensation within an amyloid-compromised vascular bed.
Keywords:
amyloid‐related imaging abnormalitiesborder‐zoneposteriorposterior reversible encephalopathy syndromevulnerability modelMore Related Videos
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