Related Experiment Video

Updated: Mar 20, 2026

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

9.5K

Non-physiological potassium concentrations in commercial culture media trigger acute seizure-like activity in human

Tim Lyckenvik1,2, Julia Izsak1, Erik Arthursson1

  • 1Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 11, 413 90, Göteborg, Gothenburg, Sweden.

Scientific Reports
|March 19, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Cell culture mediaExtracellular ion concentrationsMicroelectrode arrays (MEAs)Seizure-like activityiPSC-derived neurons

More Related Videos

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems
06:28

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

3.4K
Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
10:24

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

15.5K

Related Experiment Videos

Last Updated: Mar 20, 2026

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

9.5K
Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems
06:28

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

3.4K
Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
10:24

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

15.5K

Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

906
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
906

Articles linked to this work by shared authors, journal, and citation graph.

Cerebrospinal Fluid Biomarkers in Opioid Dependence: Evidence of Neuroimmune Activation and Ion Composition Changes, Without Alteration in Orexin-A.

Addiction biology·2025

Expression of anti-amyloid CARs in microglia promotes efficient and selective phagocytosis of Aβ1‒42.

Gene therapy·2025

Evaluation of mechanisms involved in regulation of intrinsic excitability by extracellular calcium in CA1 pyramidal neurons of rat.

Journal of neurochemistry·2024

Labile glutamate synaptic transmission in the adult CA1 stratum-lacunosum-moleculare region.

The European journal of neuroscience·2024

Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor.

Cell reports·2024

Upregulation of the Endogenous Peptide Antisecretory Factor Enhances Hippocampal Long-term Potentiation and Promotes Learning in Wistar Rats.

Neuroscience·2022

Searching for separation between frequency-modulated calls of blue and fin whales.

Scientific reports·2026

Isolation and characterization of plant plasma membrane P-type H+-ATPase dimers.

Scientific reports·2026

Cold-induced vasomotion changes in healthy individuals and patients after median or ulnar nerve repair.

Scientific reports·2026

Integrated expression profiling reveals molecular crosstalk between CFTR, FASN, FRAP (mTOR), and BANK1 in hepatocellular carcinoma.

Scientific reports·2026

Low-cost IoT real-time environmental monitoring and one-hour LSTM forecasting for small-scale agricultural applications.

Scientific reports·2026

Emotion regulation strategy use and daily levels of affective arousal, affective valence and dissociation in a clinical sample.

Scientific reports·2026

Breaking Bottlenecks in Solid Electrolyte Discovery With Large Artificial Intelligence Models.

Advanced materials (Deerfield Beach, Fla.)·2026

Unveiling Hidden Patterns in Electrode-Electrolyte Interphase Chemistry and Architecture Through Machine Learning-Assisted Mass Spectrometry Analysis.

Small methods·2026

Electrochemical Investigation of Compatibility Between Chloride- and Sulfide-Based Solid Electrolytes Using Four-Electrode Cells.

Small science·2026

Protocol for Single-Cell Patch-Proteomics: identify specific proteins associated with electrophysiological properties from individual neurons.

bioRxiv : the preprint server for biology·2026

Synergistic Electrostatic and Mechanical Anchoring at Cathode-Current Collector Junctions for Durable Sodium-Ion Batteries.

Small (Weinheim an der Bergstrasse, Germany)·2026

Zirconium-free sodium ion conducting NASICON-type structure NaMAl(PO4)3 (M = Nb, Ta).

Physical chemistry chemical physics : PCCP·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us