Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

7.8K
Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
7.8K
The Cell Cycle Control System02:11

The Cell Cycle Control System

14.8K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
14.8K
The Cell Cycle Control System02:11

The Cell Cycle Control System

9.2K
9.2K
The Cell Cycle Control System01:28

The Cell Cycle Control System

6.3K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
6.3K
Neural Circuits01:25

Neural Circuits

3.2K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DNA Cut-Ligation Cyclization Surpasses Jacobson-Stockmayer J-Factor Expectations by over Threefold.

Biomolecules·2026
Same author

Probing the limits of genetic recoding using multi-omics-guided evolution.

Nature communications·2026
Same author

Derivation of elephant induced pluripotent stem cells.

Nature methods·2026
Same author

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM.

Cell·2026
Same author

Programmable Nucleic Acid Sensing in Human Cells Using Circularizable ssDNA.

Nature communications·2026
Same author

Ultrastructural and atomic characterization of biofilm-associated extracellular filaments in Shewanella oneidensis MR-1.

Nature communications·2026
Same journal

Inside the new political screening that's stalling NIH grants.

Nature·2026
Same journal

Europe's record heatwave: does the continent have a new climate?

Nature·2026
Same journal

Daily briefing: Humans and great apes giggle in the same rhythms.

Nature·2026
Same journal

The surprising career parallels between footballers and researchers.

Nature·2026
Same journal

I study World Cup penalty shoot-outs: they say a lot about the psychology of performance under pressure.

Nature·2026
Same journal

CRISPR's next act: the companies editing the epigenome to treat disease.

Nature·2026
See all related articles
  1. Home
  3. Synthetic Circuits For Cell Ratio Control.
  1. Home
  3. Synthetic Circuits For Cell Ratio Control.

Related Experiment Video

Rapid Development of Cell State Identification Circuits with Poly-Transfection
09:21

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

2.0K

Synthetic circuits for cell ratio control.

Bolin An1,2,3, Tzu-Chieh Tang4,5, Qian Zhang1

  • 1State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Nature
|March 19, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Scientists developed new genetic tools to precisely control cell population ratios for diverse applications. These recombinase-based systems enable the creation of synthetic consortia and multicellular assemblies with tailored functionalities.

More Related Videos

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.8K
Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

2.9K

Related Experiment Videos

Rapid Development of Cell State Identification Circuits with Poly-Transfection
09:21

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

2.0K
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.8K
Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

2.9K

Area of Science:

  • Synthetic Biology
  • Genetic Engineering
  • Cellular Engineering

Background:

  • Genetic engineering offers tools to diversify cell populations.
  • Controlling ratios of multiple cell types from a single founder is challenging.

Purpose of the Study:

  • To introduce genetic devices for precise control over cell population ratios.
  • To enable the distribution of distinct functionalities across multiple cell types.

Main Methods:

  • Developed recombinase-mediated genetic devices.
  • Systematically evaluated recombination efficiency parameters.
  • Created data-driven models to predict cell differentiation outcomes.
  • Constructed parallel and series circuit topologies for cell-fate branching.

Main Results:

  • Achieved accurate control over cell population ratios.
  • Enabled autonomous differentiation of precision fermentation consortia (yeast) and mammalian cells.
  • Engineered multicellular aggregates with genetically encoded morphologies.
  • Demonstrated optimization of cell-type ratios for pigmentation and cellulose degradation.

Conclusions:

  • Recombinase-based cell-fate branching provides a robust method for synthetic biology.
  • This approach facilitates the construction of synthetic consortia and multicellular assemblies.
  • Offers precise control over cell-type ratios for diverse applications.