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Updated: Mar 20, 2026
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Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
Published on: May 30, 2016
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Advances in In Vitro Vascularization of Engineered Tissues: From Microvessel Formation to Hepatic Tissue Integration
Yen-Hsiang Huang1, Akira Ono1, Ryo Sudo1,2
1School of Integrated Design Engineering, Graduate School of Science and Technology, Keio University, Japan.
Regenerative Therapy
|March 19, 2026
Summary
Creating vascularized three-dimensional (3D) tissues is crucial for organ development. Bioengineering strategies integrating vascular biology and materials science show promise for functional 3D tissue construction.
Area of Science:
- Bioengineering
- Tissue Engineering
- Vascular Biology
Background:
- Tissue engineering has succeeded with 2D and avascular 3D tissues.
- Fully functional 3D tissues and organs remain a significant challenge.
- Vascularization is critical for nutrient/oxygen delivery in 3D constructs.
Purpose of the Study:
- Review the current status and future perspectives of in vitro tissue engineering.
- Focus on the vascularization of 3D tissues from a bioengineering viewpoint.
- Highlight strategies for vascularizing liver and other organ models.
Main Methods:
- Summarize progress in in vitro microvessel construction.
- Discuss microfluidic and bioprinting approaches for vascularization.
- Examine the liver as a model parenchymal tissue for drug discovery.
Main Results:
- Recent advances in constructing capillaries and microvessels are presented.
- Emerging strategies for vascularizing liver and other organ models are highlighted.
- The integration of bioengineering with multiple scientific disciplines is key.
Conclusions:
- Bioengineering biomimetic systems with stable vasculature are achievable.
- Functional integration with parenchymal structures is essential.
- This field opens new avenues for drug discovery, disease modeling, and regenerative medicine.
