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Sarcoid Uveitis with Choroidal Involvement
Elli Joukainen1,2, Jaakko A Antonen1, Sanna Leinonen1,3
1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Clinical Ophthalmology (Auckland, N.Z.)
|March 19, 2026
Summary
Choroidal involvement is common in sarcoid uveitis, affecting 32% of patients. Early detection through ocular imaging is crucial, as it may be missed with standard examination alone.
Area of Science:
- Ophthalmology
- Immunology
- Systemic Diseases
Background:
- Sarcoid uveitis is an inflammatory condition affecting the eye.
- Choroidal involvement can occur but its prevalence and characteristics are not fully understood.
Purpose of the Study:
- To investigate the characteristics of choroidal involvement in patients with sarcoid uveitis.
- To determine the prevalence and diagnostic challenges of choroidal involvement in sarcoid uveitis.
Main Methods:
- Retrospective analysis of 97 patients with confirmed sarcoidosis and uveitis.
- Ocular examinations including slit-lamp and ocular imaging were performed between January 2014 and January 2021.
- Analysis of choroidal involvement patterns, including nodules and types of choroiditis.
Main Results:
- Choroidal involvement was detected in 32% (31/97) of patients, with 5 cases identified only through ocular imaging.
- Common findings included multifocal choroiditis (90%) and choroidal nodules (10%).
- Patients with choroidal involvement showed higher rates of chronic uveitis, bilateral disease, vitreal snowballs, and macular edema.
Conclusions:
- Choroidal involvement is a frequent manifestation of sarcoid uveitis and is often underdiagnosed.
- Ocular imaging is recommended in addition to slit-lamp examination for comprehensive assessment of choroidal involvement in sarcoid uveitis.
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