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Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
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Subtype-specific modulation of inhibitory interneurons by general anesthetics

Taisuke Sugino1, Takuya Okada1, Yuki Nomura1

  • 1Division of Anesthesiology, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.

Iscience
|March 19, 2026
PubMed
Summary

Ketamine uniquely activates more excitatory and somatostatin (SST) interneurons compared to isoflurane and propofol. This selective neuronal activation reveals distinct cortical changes during general anesthesia.

Keywords:
Biological sciencesCellular neuroscienceMolecular neuroscienceNatural sciencesNeuroscience

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