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Influence of the Gut Microbiome on Body Composition and Metabolic Risk in Indian Children with Type 1 Diabetes

Vaishali Tamhane1, Nikhil Shah2, Anuradha V Khadilkar3

  • 1Department of Research, Hirabai Cowasji Jehangir Medical Research Institute (HCJMRI), Pune, Maharashtra, India.

Journal of Pharmacy & Bioallied Sciences
|March 19, 2026
PubMed

Insights

Gut microbiome differs in children with Type 1 diabetes (T1DM) based on metabolic risks. This study highlights variations in gut flora composition, crucial for understanding T1DM complications.

Area of Science:

  • Microbiology
  • Pediatric Endocrinology
  • Metabolic Disorders

Background:

  • Type 1 diabetes (T1DM) management is complex, with metabolic risks (MR) influencing disease progression.
  • Gut microbiome alterations are increasingly linked to metabolic health and autoimmune conditions like T1DM.

Purpose of the Study:

  • To investigate gut flora differences in children with T1DM.
  • To compare gut microbiome composition between T1DM children with and without metabolic risks.

Main Methods:

  • Cross-sectional observational study of 68 children with T1DM.
  • Analysis of gut microbiome using 16S rRNA gene sequencing on stool samples.
  • Assessment of clinical history, anthropometry, biochemical markers, and body composition.

Main Results:

  • Significant differences in gut microbiome composition were found at family and genera levels.
  • Variations were observed between T1DM children with metabolic risks versus those without.

Conclusions:

  • Gut microbiome composition significantly differs between T1DM children with and without metabolic risks.
  • These findings underscore the role of gut flora in T1DM-associated metabolic complications.
Abstract

Keywords:
Body compositionchildrengut microbiomemetabolic risktype 1 diabetes mellitus

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