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Neglected Tropical Diseases: A Systematic Review.

Sandip Ganpatbhai Patel1, Mahir Modi2, Kavya Darji2

  • 1General Medicine, Anjani Hospital and ICU, Government Medical College, Surat, Gujarat, India.

Journal of Pharmacy & Bioallied Sciences
|March 19, 2026
PubMed
Summary

Neglected Tropical Diseases (NTDs) disproportionately impact low-income nations, causing significant disability and poverty. Addressing these diseases requires integrated primary care, sustainable funding, and multisectoral strategies to meet global elimination goals.

Keywords:
Global burdenWASHneglected tropical diseasespolicypublic healthuniversal health coverage

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Area of Science:

  • Global Health
  • Infectious Diseases
  • Public Health Policy

Background:

  • Neglected Tropical Diseases (NTDs) affect over a billion people, causing substantial morbidity, disability, and poverty, particularly in low- and middle-income countries.
  • These diseases receive insufficient global health policy attention and funding, hindering progress towards control and elimination.
  • The COVID-19 pandemic has exacerbated existing challenges, including health disparities and disruptions to essential services.

Purpose of the Study:

  • To systematically review recent literature (2018-2024) on the burden, interventions, and policies related to Neglected Tropical Diseases.
  • To identify effective strategies and persistent research gaps in addressing NTDs.
  • To inform global health strategies for achieving 2030 NTD elimination targets.

Main Methods:

  • A systematic literature search was performed across PubMed, Scopus, and Web of Science.
  • Inclusion criteria focused on original research, policy reviews, and global reports on WHO-recognized NTDs published between 2018 and 2024.
  • Data from 15 selected articles were synthesized thematically.

Main Results:

  • Significant geographical and health disparities in NTD burden were identified.
  • Underfunding, poor integration into primary care, and COVID-19 disruptions were major challenges.
  • Effective strategies include Water, Sanitation, and Hygiene (WASH) integration, translational technologies, and alignment with Universal Health Coverage.
  • Research gaps exist in pediatric populations and community engagement.

Conclusions:

  • Addressing NTDs necessitates resilient, multisectoral approaches integrated within primary healthcare systems.
  • Prioritizing equity, local adaptation, and sustainable financing is crucial for achieving 2030 elimination targets.
  • Strengthening primary healthcare is essential for effective NTD control and prevention.