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Oral Transmission of Listeria monocytogenes in Mice via Ingestion of Contaminated Food
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Listeria Monocytogenes: A Case Series and Clinical Insights from a Tertiary Care Hospital

Nidhi Sharma1, Abhishek Sharma2, Vismit Mungi3

  • 1Department of Microbiology, GMC Datia, Madhya Pradesh, India.

Journal of Pharmacy & Bioallied Sciences
|March 19, 2026
PubMed

Insights

A cluster of six Listeria monocytogenes bacteremia cases occurred in immunocompromised patients. Early diagnosis and antibiotic treatment led to positive outcomes for most patients, highlighting listeriosis as a significant concern.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Listeria monocytogenes causes severe invasive infections like bacteremia and meningitis, particularly in immunocompromised individuals.
  • Untreated infections have a high mortality rate due to insidious presentation.

Purpose of the Study:

  • To report a cluster of six Listeria monocytogenes bacteremia cases at a tertiary care center.
  • To emphasize the importance of early diagnosis and treatment for listeriosis in at-risk patients.

Main Methods:

  • Blood cultures were used to confirm infections.
  • The VITEK 2 system identified the organisms.
  • Antibiotic sensitivity testing was performed.

Main Results:

  • Six cases of Listeria monocytogenes bacteremia were identified over 10 months.
  • Patients ranged from 27-72 years old, with four having immunosuppressive conditions.
  • All isolates were sensitive to gentamicin and ampicillin.
  • Five patients recovered with intravenous antibiotic therapy; one patient died from multiorgan failure.

Conclusions:

  • Listeriosis remains a significant concern in febrile patients with predisposing conditions.
  • Prompt diagnosis and appropriate antibiotic intervention are crucial for favorable patient outcomes.
Keywords:
AmpicillinListeria monocytogenesbacteremiacase seriesimmunocompromisedlisteriosistertiary care

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