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Related Experiment Video

Updated: Mar 20, 2026

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Pulmonary mycoses: a clinical perspective.

Klara Verstappen1,2, Cédric Bosteels1,2, Eva Van Braeckel1,2

  • 1Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

Breathe (Sheffield, England)
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Pulmonary mycoses are diverse fungal infections affecting the lungs. Early diagnosis and prompt treatment, utilizing advanced imaging and markers like beta-glucan, are crucial for managing these complex diseases.

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Area of Science:

  • Pulmonology and Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Pulmonary mycoses involve various fungi, with susceptibility linked to immune defects and barrier disruption.
  • Clinical and radiological presentations are highly variable, necessitating accurate diagnostics.

Purpose of the Study:

  • To review current knowledge on pulmonary mycoses.
  • To highlight practical considerations for diagnosis and management.

Main Methods:

  • Synthesis of current literature on epidemiology, clinical and radiological features.
  • Review of diagnostic methods including imaging, histopathology, and biomarkers.
  • Assessment of therapeutic options, including emerging agents and immunotherapy.

Main Results:

  • Pulmonary mycoses present diversely, from colonization to life-threatening disease.
  • High-resolution CT aids diagnosis, but histopathology remains gold standard.
  • (1→3)-β-d-glucan and other markers guide diagnosis; culture-based and non-culture-based tests are essential for pathogen identification.

Conclusions:

  • Prompt, guideline-concordant therapy is emphasized.
  • Emerging antifungal agents and immunotherapies offer hope for resistant cases.
  • Integrated diagnostic approaches are key for effective management of pulmonary fungal infections.