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Updated: Mar 20, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Near-complete pathologic resolution of untreated papillary thyroid cancer after pembrolizumab-induced thyroiditis
Margaret Locke1, Sara Sternbach2, Nagashree Seetharamu1
1Department of Hematology/Oncology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, USA.
Abstract:
Immune checkpoint inhibitors (ICIs) have revolutionized treatment for multiple cancers. However, research into the therapeutic potential of ICIs for differentiated thyroid cancer (DTC) is sparse. We present a case of a 55-year-old woman with untreated papillary thyroid cancer who received pembrolizumab as part of treatment for her breast cancer and then developed pembrolizumab-induced destructive thyroiditis, leading to near-complete pathologic resolution of her thyroid cancer. This suggests therapeutic potential to use ICIs in patients with DTCs who are not candidates for standard therapies such as surgical resection, and as an additional agent for patients with advanced metastatic DTC.
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