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A Link Between the Triglyceride-Glucose Index and the Risk of Hypertension Among Employees in the Titanium Dioxide

Fengni Qin¹, Guangzi Qi¹, Suren Sooranna^2,3

¹School of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, People's Republic of China.

Vascular Health and Risk Management

|March 19, 2026

Abstract

Purpose:

The TyG index is a reliable marker of insulin resistance, and studies suggest its association with hypertension risk. However, no relevant research has been conducted among employees of titanium dioxide (TiO₂) manufacturing enterprises. This study aims to investigate the association between the TyG index and hypertension risk in this population.

Methods:

This study employed a cross-sectional design, conducting questionnaire surveys and health examinations among 596 employees at a titanium dioxide manufacturing enterprise in Guangxi. The TyG index was calculated, and the relationship between TyG and hypertension risk, along with its predictive value, was analyzed using multivariate logistic regression, restricted cubic splines, and ROC curve analysis.

Results:

The prevalence of hypertension among titanium dioxide workers was 17.22%. Univariate analysis showed that age, gender, work experience, alcohol consumption, hyperglycemia, abnormal liver function, dyslipidemia, and the TyG index were associated with hypertension (P<0.05). Multivariate analysis revealed that the hypertension risk in the highest TyG quartile (Q4) was 11.12 times higher than that in the lowest quartile (Q1) (95% CI: 3.52-35.16). Results from the restricted cubic spline model indicated a nonlinear association between the TyG index and hypertension risk (P for overall < 0.0001, P for nonlinearity < 0.0001). Stratified analysis confirmed the TyG index as a major risk factor with a positive effect (P < 0.05). The ROC curve AUC was 0.775, indicating that the TyG index has good predictive ability for hypertension.

Conclusion:

A high TyG index increases the risk of hypertension among workers in titanium dioxide production enterprises. As a low-cost, easily implemented early screening tool, the TyG index facilitates early identification and intervention for high-risk populations, providing scientific basis for developing targeted intervention measures for hypertension and cardiovascular health among occupational populations.

Keywords:

correlation employees of titanium dioxide manufacturing companies hypertension triglyceride-glucose index

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