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Updated: Mar 20, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
Elevated Peripheral White Blood Cell Count and Lower Urinary Tract Symptom Risk: A Population-Based Cross-Sectional
Zheng Lu1, Jiange Zhang2, Zhenyuan Yu1
1Department of Urology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Objective:
To investigate the association between peripheral white blood cell (WBC) count and lower urinary tract symptoms (LUTS) in a male population.
Study Design And Setting:
A population-based cross-sectional survey was conducted among males aged 18-88 years in Fangchenggang, Guangxi, China, from July to November 2011. Using multistage cluster sampling, 4,694 participants were enrolled. Multivariable logistic regression models assessed the WBC-LUTS association.
Results:
The prevalence of moderate/severe LUTS was 6.67%. Compared to men with none/mild LUTS, those with moderate/severe LUTS had significantly higher mean WBC counts (P<0.01). Elevated WBC levels were independently associated with increased risks of overall LUTS (OR=1.93; 95% CI: 1.40-2.66) and voiding symptoms (OR=1.68; 95% CI: 1.19-2.35) after adjusting for confounders. Specifically, higher WBC quartiles (Q3-Q4) showed significantly greater prevalence of intermittency and urgency versus the lowest quartile (Q1). Additional risk factors for LUTS included age, hypertension, lower education, diabetes mellitus, and alcohol consumption.
Conclusion:
LUTS severity positively correlates with peripheral WBC counts, suggesting systemic inflammation may contribute to LUTS pathogenesis.
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