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Updated: Mar 20, 2026
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Author Spotlight: Leptospira DNA Detection in Water for Environmental Analysis and Disease Surveillance
Published on: June 14, 2024
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[Leptospirosis]
Louise Rønnau Ejrnæs1, Andreas Arnholdt Pedersen2,3,4, Frederikke Christina Knudtzen2,3,5
1Onkologisk Afdeling R, Odense Universitetshospital.
Ugeskrift for Laeger
|March 19, 2026
Summary
Severe leptospirosis in Denmark led to multi-organ failure in two patients. Prompt intensive care, including antibiotics, resulted in clinical improvement and discharge for both individuals.
Area of Science:
- Infectious Diseases
- Nephrology
- Critical Care Medicine
Background:
- Leptospirosis is a zoonotic bacterial infection with potential for severe systemic complications.
- Multi-organ failure is a critical manifestation of severe leptospirosis.
- Geographic location of infection can influence pathogen strains and disease presentation.
Purpose of the Study:
- To report two cases of severe leptospirosis with multi-organ failure in Denmark.
- To highlight diagnostic methods and clinical management of severe leptospirosis.
- To emphasize the importance of intensive care in managing life-threatening leptospirosis.
Main Methods:
- Case report methodology.
- Diagnostic confirmation using cerebrospinal fluid PCR and urine Leptospira testing.
- Intensive care unit management including vasopressors and antibiotics.
Main Results:
- Two patients presented with severe leptospirosis and multi-organ failure following infection in Denmark.
- One patient developed cerebrospinal fluid abnormalities, while the other experienced cardiopulmonary failure.
- Both patients showed clinical improvement with intensive medical intervention.
Conclusions:
- Severe leptospirosis can lead to multi-organ failure, even in previously healthy individuals.
- Early diagnosis and aggressive intensive care are crucial for favorable outcomes in severe leptospirosis.
- This case series underscores the potential severity of leptospirosis in temperate regions like Denmark.
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