Related Experiment Video

Updated: Mar 21, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K

Comparison of bleeding complications between patients with peripheral and coronary artery disease after

Kazunori Horie1, Mitsuyoshi Takahara2, Yoshimitsu Soga3

  • 1Department of Cardiovascular Medicine, Sendai Kousei Hospital, Miyagi, Japan.

Vascular Medicine (London, England)
|March 19, 2026
PubMed

Insights

Patients with peripheral artery disease (PAD) have higher bleeding risk factors and incidence rates compared to coronary artery disease (CAD) patients. However, after adjustment, PAD did not significantly increase major bleeding events, suggesting risk factors drive the difference.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Clinical Research

Background:

  • Peripheral artery disease (PAD) and coronary artery disease (CAD) are common vascular conditions.
  • Revascularization procedures are used to treat both PAD and CAD.
  • Bleeding complications are a significant concern following revascularization.

Purpose of the Study:

  • To compare the incidence and risk of major bleeding between patients undergoing revascularization for PAD and CAD.
  • To identify factors contributing to bleeding risk in these patient populations.

Main Methods:

  • Subanalysis of the ASPARAGUS study including 4343 PAD patients and 6238 CAD patients.
  • Application of Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria.
  • Primary endpoint: cumulative incidence of major bleeding (Bleeding Academic Research Consortium types 3 and 5).

Main Results:

  • Patients with PAD had higher ARC-HBR scores (61.5% major, 79.3% minor criteria) than CAD patients (32.0% major, 65.9% minor criteria).
  • Crude incidence rate of major bleeding was higher in PAD (19.1/1000 person-years) vs. CAD (10.7/1000 person-years).
  • Adjusted analysis showed no significant association between PAD and incident major bleeding (aIRR=1.14, p=0.22).

Conclusions:

  • PAD patients exhibit higher bleeding risk factors and crude major bleeding incidence compared to CAD patients.
  • The elevated bleeding risk in PAD is primarily attributed to a higher prevalence of ARC-HBR-defined risk factors.
  • After accounting for these risk factors, PAD itself was not a significant independent predictor of major bleeding events.
Abstract

Keywords:
bleeding complicationcoronary artery disease (CAD)endovascular therapypercutaneous interventionperipheral artery disease (PAD)

More Related Videos

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.7K
Establishment and Evaluation of a Porcine Vein Graft Disease Model08:50

Establishment and Evaluation of a Porcine Vein Graft Disease Model

Published on: July 25, 2022

2.3K

Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
551
Cardiac Catheterization II: Right Heart Catheterization01:21

Cardiac Catheterization II: Right Heart Catheterization

Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
1.7K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
627
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
391
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
539
Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
1.0K