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Formation of Halohydrin from Alkenes02:41

Formation of Halohydrin from Alkenes

15.0K
An alkene, such as propene, reacts with bromine in the presence of water to yield a halohydrin. Halohydrins contain a halogen and a hydroxyl group attached to adjacent carbons. When the halogen is bromine, it is called a bromohydrin, while a chlorohydrin has chlorine as the halogen.
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Alkyl Halides02:45

Alkyl Halides

21.3K
Structural Properties
Alkyl halides are halogen-substituted alkanes wherein one or more hydrogen atoms of an alkane is replaced by a halogen atom such as fluorine, chlorine, bromine, or iodine. The carbon atom in an alkyl halide is bonded to the halogen atom, which is sp3-hybridized and exhibits a tetrahedral shape.
Unlike alkyl halides, compounds in which a halogen atom is bonded to an sp2 -hybridized carbon atom of a carbon-carbon double bond (C=C) are called vinyl halides. Whereas aryl...
21.3K
Aldehydes and Ketones with Water: Hydrate Formation01:20

Aldehydes and Ketones with Water: Hydrate Formation

5.3K
An oxygen-based nucleophile, like water, can undergo addition reactions with aldehydes and ketones. The reaction leads to the formation of hydrates, also referred to as 1,1-diols or geminal diols.
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
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Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration02:34

Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration

9.9K
The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
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Molecular Shape and Polarity03:37

Molecular Shape and Polarity

77.1K
Dipole Moment of a Molecule
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Protection of Alcohols02:31

Protection of Alcohols

8.2K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
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Related Experiment Video

Updated: Mar 21, 2026

Preparation of Hydrophobic Metal-Organic Frameworks via Plasma Enhanced Chemical Vapor Deposition of Perfluoroalkanes for the Removal of Ammonia
12:05

Preparation of Hydrophobic Metal-Organic Frameworks via Plasma Enhanced Chemical Vapor Deposition of Perfluoroalkanes for the Removal of Ammonia

Published on: October 10, 2013

16.1K

Perfluorinated alkyl groups induce unexpected hydrophobic hydration structure.

Simon Schulke1, Elio Casalini2, Jaspreet Kaur1

  • 1Faculty for Chemistry and Biochemistry, Ruhr-University Bochum, Universitätsstraße 150, 44801 Bochum, Germany. Martina.Havenith@ruhr-uni-bochum.de.

Physical Chemistry Chemical Physics : PCCP
|March 19, 2026
PubMed
Summary
This summary is machine-generated.

Perfluorination alters ethanol

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Area of Science:

  • Physical Chemistry
  • Solution Chemistry
  • Spectroscopy

Background:

  • Perfluorination of ethanol's methyl group impacts water mixing thermodynamics.
  • Understanding these differences is crucial for predicting solubility of fluorinated compounds.

Purpose of the Study:

  • To investigate the structural and thermodynamic origins of differing mixing behaviors between ethanol (EtOH) and 2,2,2-trifluoroethanol (TFE) in water.
  • To elucidate the role of hydrogen bonding and collective vibrational modes.

Main Methods:

  • Terahertz (THz) spectroscopy to probe solution dynamics.
  • Molecular dynamics simulations to analyze structure and hydrogen bonding.

Main Results:

  • THz spectra revealed distinct entropy- and enthalpy-related features linked to water-water and water-solute hydrogen bonds.
  • TFE solutions showed a red-shift in the entropy peak, indicating weaker water-water hydrogen bonds in the solvation shell.
  • Simulations identified three key effects influencing mixing thermodynamics: altered water-water hydrogen bonding, differential perturbation of water molecules, and varying solute-water hydrogen bond strength.

Conclusions:

  • Hydrophobic solvation of perfluorinated groups differs significantly from alkylated groups.
  • The study provides insights into the fundamental interactions governing the solubility of perfluorinated molecules.