Related Experiment Video
Updated: Mar 21, 2026
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
Systemic immune-inflammation index may be used to predict the development of colorectal cancer from colonic polyps
Ying Chun1, Jing Xia1, Chaosheng Peng1
1Department of Day Clinic, The Six Medical Center of PLA General Hospital, Beijing, China.
Aims:
This study aims to assess whether the Systemic Immune-Inflammation Index (SII) can serve as a predictive biomarker for the progression of colonic polyps to colorectal cancer (CRC).
Patients & Methods:
A total of 351 individuals (236 with colonic polyps and 115 with CRC) who underwent colonoscopy and received a pathological diagnosis at The Six Medical Center of PLA General Hospital were included. Demographic, clinical, and laboratory data were collected. SII was calculated using neutrophil, monocyte, and lymphocyte counts. Statistical analyses, including univariate and multivariate logistic regression, identified risk factors for CRC development, and receiver operating characteristic (ROC) curves were used to assess the diagnostic performance of SII and CEA.
Results:
SII was significantly higher in CRC patients compared to those with colonic polyps (P < 0.001). Univariate and multivariate analyses revealed that SII, CEA, and lymphocyte count were independent predictors of CRC. ROC analysis showed that SII had a good diagnostic performance with an AUC of 0.823, sensitivity of 80.9%, and specificity of 72.0%.
Conclusions:
SII is a promising, noninvasive biomarker for identifying patients at increased risk of CRC among those with colonic polyps. Further prospective studies are needed to confirm these findings.
Related Concept Videos
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...