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A qualitative analysis of cancer patients' views on facilitators and barriers for the implementation of oncological exercise therapy.

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Updated: Jul 10, 2026

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach
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Supportive care: Comparing exercise interventions for upper extremity polyneuropathy induced by chemo- or

Stefanie Siebert1,2, Jane Kersten3, Sarah Man3

  • 1Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital of Cologne, Kerpener Str. 62, Cologne, 50937, Germany. stefanie.siebert@uk-koeln.de.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|March 19, 2026
PubMed
Summary

Supervised exercise, particularly combined sensorimotor and vibration therapy, effectively reduced chemotherapy-induced peripheral neuropathy (PNP) symptoms in cancer patients' upper extremities. This pilot study demonstrated feasibility and significant patient-reported improvements, warranting further investigation in larger trials.

Keywords:
Cancer treatment toxicitySensorimotor exerciseSupportive careTherapy-induced peripheral neuropathyUpper extremitiesVibration intervention

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Area of Science:

  • Oncology
  • Neurology
  • Rehabilitation Medicine

Background:

  • Peripheral neuropathy (PNP) affects up to 68% of cancer patients due to chemotherapy and immunotherapy, often persisting post-treatment and impacting quality of life.
  • While exercise benefits lower-limb PNP, evidence for upper-extremity symptoms is limited.
  • The VISCIPH B pilot study explored supervised exercise interventions for upper-extremity PNP.

Purpose of the Study:

  • To assess the feasibility, safety, and efficacy of two supervised exercise interventions for cancer patients with upper-extremity peripheral neuropathy.
  • To compare the effects of combined sensorimotor plus vibration exercise (PNPEX) versus moderate resistance exercise (MREX).

Main Methods:

  • A single-center randomized controlled pilot trial involving 61 cancer patients with symptomatic upper-extremity PNP.
  • Participants were randomized to PNPEX or MREX, with supervised sessions twice weekly for 12 weeks.
  • Feasibility outcomes included adherence, retention, and safety. Symptom outcomes were measured using FACT/GOG-Ntx, NRS pain scale, Rydel-Seiffer tuning fork, and EORTC QLQ-C30 quality of life questionnaire.

Main Results:

  • High adherence (86%) and retention (69%) were observed, with no intervention-related adverse events.
  • The PNPEX group showed significantly greater improvement in FACT/GOG-Ntx scores compared to MREX (p=0.05).
  • PNPEX participants reported significant improvements in numbness, tingling, depth sensitivity, and global health (p=0.001).

Conclusions:

  • Supervised exercise, specifically combined sensorimotor and vibration exercise, is feasible, safe, and well-accepted for managing upper-extremity PNP in cancer patients.
  • This intervention demonstrated meaningful reductions in PNP symptoms and functional improvements.
  • Larger trials are recommended to further validate these findings.