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Multitarget Anticoccidial Activity of Olive Seed Phenolic Compounds Against Eimeria spp.: Insights from Molecular

Nedjima Debbou-Iouknane1, Rachida Amokrane-Aidat2, Sonia Oukhmanou-Bensidhoum2

  • 1Centre de Recherche en Technologies Agro-Alimentaires, Route de Targa Ouzemmour, Campus Universitaire, 06000, Bejaia, Algeria.

Acta Parasitologica
|March 19, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Eimeria spp.Olea europeae LAnticoccidial activityMultitarget interactionOlive seed extract

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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