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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
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Updated: Mar 21, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
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The biodesign framework: professional biodesign practices.

Bert Vuylsteke1, Louise Dumon1, Jan Detand1

  • 1Department of Industrial Systems Engineering and Product Design, Ghent University Campus Kortrijk, Kortrijk, Belgium.

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Summary

This study explores biodesign professionalization, investigating how designers engage with biology. A new framework is proposed to guide the growth of this regenerative design field.

Keywords:
biodesigncircular economyindustrial design engineeringmethodological frameworkregenerative economy

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Area of Science:

  • Design Engineering
  • Biotechnology
  • Sustainability Studies

Background:

  • Biodesign offers potential for circular and regenerative solutions.
  • Industrial application of biodesign remains limited, hindering its growth.
  • Understanding designer motivations and practices is crucial for professionalization.

Purpose of the Study:

  • To investigate the motivations and practices of professional biodesign pioneers.
  • To explore why and how designers engage in designing with, of, and for biology.
  • To propose a methodological framework for biodesign professionalization.

Main Methods:

  • Qualitative analysis using the QUAGOL methodology.
  • Extensive expert interviews with 21 biodesign pioneers.
  • Identification and investigation of five key biodesign codes and their sub-codes.

Main Results:

  • Identified five key codes: biodesign mindset, -process, -resources, -materials, and -future.
  • Detailed evidence-based findings into current biodesign practices.
  • A novel methodological biodesign framework was developed.

Conclusions:

  • The proposed framework maps nested environments and a cybernetical loop for human-more-than-human interaction.
  • This framework provides a structured approach for biodesign professionalization.
  • The framework supports future empirical validation and tool development in biodesign education and practice.