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Design, synthesis, and biological evaluation of novel hydrophobic tag-based degraders targeting JNK1

Yi Huang1, Man Chi2, Ye Zhang2

  • 1State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210023, China; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.

Bioorganic Chemistry
|March 19, 2026
PubMed

Keywords:
C-Jun N-terminal kinaseEpithelial-mesenchymal transitionHydrophobic taggingProtein degradation

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