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Does local bisphosphonate application or surface coating improve implant success? A systematic review
F Pérez-González1, L Sánchez-Labrador1, L M Sáez-Alcaide1
1Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, Spain.
Journal of Stomatology, Oral and Maxillofacial Surgery
|March 19, 2026
Summary
Local bisphosphonate application on dental implants shows potential but lacks conclusive evidence for improving osseointegration or reducing bone loss. Further clinical trials are needed to confirm benefits for peri-implant bone health.
Area of Science:
- Biomaterials Science
- Dental Implantology
- Pharmacology
Background:
- Dental implant success relies on osseointegration and maintaining peri-implant bone.
- Bisphosphonates are known to inhibit bone resorption, suggesting potential benefits for implant stability.
Purpose of the Study:
- To systematically review the effectiveness of local bisphosphonate application and surface coating on dental implants.
- To evaluate the impact on clinical outcomes such as osseointegration and marginal bone loss.
Main Methods:
- A comprehensive systematic review and meta-analysis was performed.
- Searches were conducted in PubMed/MEDLINE, Web of Science, and Scopus databases up to November 2025.
- A PRISMA-based protocol guided the review process.
Main Results:
- Current evidence does not conclusively support that local bisphosphonate use enhances osseointegration.
- No definitive decrease in marginal bone loss was observed with bisphosphonate application.
- Insufficient data exists to establish a clear clinical benefit for bisphosphonate-modified implants.
Conclusions:
- Bisphosphonate-enhanced implant surfaces present a promising concept for improving bone integration.
- Further high-quality clinical trials are essential to validate the efficacy of bisphosphonates in enhancing osseointegration and peri-implant bone quality.
